We have started doing a bit of work with Flex, being a CF house mainly. The enhanced UI that we can generate with Flex and the ease of which it talks to CF is just awesome.
We are writing full applications, using.
1. Flex Front End
2. ColdFusion Back End
3. ColdFusion Report Builder for Reporting.
I have to say, that developing web based real word data centric applications like this is working out better than I had hoped. At some point in the future I might post some screen shots.
I would encourage all CF developers / managers out there to give Flex a serious look.